[SCIENCE MONDAY] - Staphylococcus aureus adapts its metabolism to each organ it infects, using different genes to survive in skin, kidney, and spleen revealing new treatment targets

Staphylococcus aureus dynamically reorganizes its metabolism to maintain fitness across distinct infected tissues. Analyses in murine models of skin, kidney, and spleen infection identified genes required in a site-specific manner. Some fitness determinants are shared, whereas others emerge only in particular microenvironments. These findings outline key metabolic adaptations and potential therapeutic vulnerabilities.

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